Antioxidant Potential Of Byesukar, A Polyherbal Formulation On Alloxan Induced Oxidative Stress In Rats Guruvayoorappan C.author Sudha G.authorByesukar, a polyherbal formulation intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, byesukar was administered orally for 30 days at a dose of 500 mg/kg body weight to alloxan induced diabetic male wistar rats. All the animals were sacrificed on the 31st day and the levels of LPO, SOD, CAT, GPx, GST and GR in kidney and liver of control and experimental rats were studied. The extracts exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione s-transferase (GST) and glutathione reductase (GR) and decreased level of lipid peroxidation. These results showed that treatment with byesukar lowers alloxan induced LPO and alters SOD, CAT, GPx, GST and GR enzymes to reduce oxidative stress.Q Science, Computer ScienceR Medicine, Dentistry, Pharmacy, Nursing2005Malaysian Society for Biochemistry and Molecular BiologyJournal